This study investigates the surface properties, micellization, and electrical conductivity of betaine-based ionic liquids (ILs) composed of [R-bet][Br] where R represents the C4, C6 and C8 (specifically [C4bet][Br], [C6bet][Br], and [C8bet][Br]) in aqueous gabapentin solutions at concentrations of (0.0000, 0.0100, 0.0300, and 0.0500) mol kg−1 at 298.15 K. The surface tension measurements revealed that increasing gabapentin concentration and alkyl chain length decrease surface tension, indicating significant hydrophobic and hydrophilic interactions. The related thermophysical micellization parameters, including critical micelle concentration (CMC) and minimum surface area per molecule (Amin), exhibited improved micellization and interfacial efficiency with longer alkyl chains. Thermodynamic analysis confirm the spontaneous nature of micelle formation, with more negative Gibbs free energy values for SAILs with longer alkyl chains. The electrical conductivity studies indicate lower limiting molar conductivity (Λ0) at higher gabapentin concentrations, due to increased viscosity and ion-ion interactions. Ion association constants (KA) and DFT-COSMO calculations support stronger hydrophobic interactions and molecular packing influenced by alkyl chain length and gabapentin. Visit for more information 8Bet Game

Betaine is known as a neutral chemical compound bearing a positively charged cationic functional group, devoid of a hydrogen atom. This is typically exemplified by a quaternary ammonium or phosphonium cation, alongside a negatively charged functional group, such as a non-adjacent carboxylate group. Known by various names including betaine anhydrous and trimethyl glycine (TMG). It is a naturally founded substance in the human body. Betaine plays a crucial role in liver function, cellular reproduction, and in the synthesis of carnitine. Notably, it facilitates the conversion of the amino acid homocysteine into methionine. With its wide availability, cost-effectiveness, and biocompatibility, surface-active properties, betaine holds promise for future applications in pharmaceutical industrial1,2,3,4.