I run the TM2sc in 2wd class.
Chose this due to the 2wd buggy performance, that I have used at regional and national level with great success.
I ran the DESC410r in 2012 and 13 and switched to team C TS4te for 2014 as parts and wheels etc are interchangable.
Taken a few rounds to find the sweet spot of the chassis but am somewhere near with a few mods of my own.
Simple rules to follow;
4wd class run 8th electrics
2wd class run 10th electrics
comes down to budget really, or if you are switching from 10th buggy.