Ive been running it for ages at home. We are rolling it out to the IT department at work over the next couple of months but a few of us have been using it for a month or two with very few issues. We run APP V too, which is fantastic.
Im running 64bit Win 7 at home on my test 'server' (PC), it handles VM Ware server and 5 VM's without even breaking a sweat, love it.
Don't hesitate to upgrade, it's in a different league to Vista.