How do you collect your email?
I've recently stopped using Thunderbird, instead prefering Google Mail - it can collect mail from other POP accounts - I like the ability to check all my mail addresses in one place, via the Internet. With the new themes installed, it's also easier to read than Thunderbird.
Google Mail also has pretty effective spam filtering (derived from feedback by all their users, not just you) - check for and unspam the odd false-positive, but it works.
When using Thunderbird, I installed the Habu plugin, and reported the spam to a swathe of sites on a frequent basis.
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