I never use the IS (called VR on mine, but same thing) - I used to just because it was there. For really (really) low shutter speed panning shots it worked a little but tbh you can get the same stabilization by using a smoother arc when panning.
For anything moving that you're not trying to get a special (slow pan) effect with, then IS really isn't worth spending extra on.
Generally with my 70-200 F2.8 I will shoot from F4 to around F11 outdoors - I find F2.8 depth of field to be just too small for most things.
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