I've been running turbo'd 10.5's in 2 and 4wd for the whole last season.

At the end of the straight they can hold their own, but they certainly don't have the same punch as a 6.5t. In particular out of slow corners they lack poke, its better further up the rev range though.
I have found a few problems with certain types of jump due to that lack of initial grunt because you can't just gun it to get a good takeoff.
However, overall reckon I drive better with them - I'm a throttle jammer anyway so the softer config just tames my natural tendencies. In 2wd in the wet its certainly better - for 4wd not so much.

Oh, and they run hot. Really hot. Really really hot! Does depend on the esc though - my GM seems to offer the most boost but runs coolest, my LRP has less boost but things get a lot hotter.